Estudi de la incidència de la simptomatologia d'ull sec

Objectiu: En aquest estudi s’ha investigat la etiologia de l’ull sec en una mostra de pacients d’un centre oftalmològic, per confirmar tres hipòtesis: la simptomatologia de l’ull sec ve determinada per l’edat, el sexe, i/o factors físics, químics o externs. Metodologia: Als pacients de la mostra se’ls va realitzar un qüestionari ad-hoc, el test OSDI i un seguit de proves no invasives per acceptar o descartar les hipòtesis plantejades. Resultats: Dels 394 pacients visitats en dies aleatoris les dues últimes setmanes de març, es va realitzar l’estudi a 40 persones. Es van classificar en tres rangs d’edat 65 anys (37.50%). La mostra presentava un percentatge de dones més elevat (77.50%). El percentatge de dones que presentava una simptomatologia d’ull sec sever o moderat segons el test OSDI era més elevat que el d’homes i tant el test OSDI com les proves no invasives realitzades indiquen una augment de la prevalença amb l’edat. Conclusió: L’edat influeix en la presència de l’afectació i n’augmenta els símptomes. El sexe també influeix en l’aparició del síndrome, les dones són més propenses a patir aquesta malaltia multifactorial, fet que confirma la segona hipòtesi de treball. Pel que fa als factors físics químics i externs es pot detectar una influència de l’activitat laboral i del dèficit de vitamina D doncs en les proves realitzades s’observa un lleuger pic de sequedat ocular a la franja entre 41-65 anys que és la franja de la mostra que presenta un percentatge més elevat de persones que treballen i presenten dèficit d’aquesta vitamina.Objetivo: En este estudio se ha investigado la etiología del ojo seco en una muestra de pacientes de un centro oftalmológico, para confirmar tres hipótesis: la sintomatología del ojo seco se determina por la edad, el sexo, y/o factores físicos, químicos o externos. Metodología: En los pacientes de la muestra se realizó un cuestionario ad-hoc, el test OSDI y un seguimiento de pruebas no invasivas para aceptar o descartar las hipótesis planteadas. Resultados: De los 394 pacientes visitados en días aleatorios las últimas semanas de marzo, se realizó el estudio a 40 personas. Se clasificó en tres rangos de edad 65 años (37,50%). La muestra presentaba un porcentaje de mujeres más elevado (77.50%). El porcentaje de mujeres que presentaba una sintomatología de ojo seco severo o moderado según el test OSDI era más elevado que el de hombres y tanto el test OSDI como las pruebas no invasivas realizadas indican un aumento de la prevalencia con la edad. Conclusión: La edad influye en la presencia de la afectación y aumenta los síntomas. El sexo también influye en la aparición del síndrome, las mujeres son más propensas a padecer esta enfermedad multifactorial, lo que confirma la segunda hipótesis de trabajo. En cuanto a los factores físicos químicos y externos se puede detectar una influencia de la actividad laboral y del déficit de vitamina D pues en las pruebas realizadas se observa un ligero pico de sequedad ocular en la franja entre 41 a 65 años que es la franja de la muestra que presenta un porcentaje más elevado de personas que trabajan y presentan déficit de esta vitamina.Objective: In this study we investigated the etiology of dry eye in a sample of patients from an ophthalmologic center, to confirm three hypotheses: dry eye symptoms are determined by age, sex, and/or physical, chemical or external factors. Methodology: An ad-hoc questionnaire, the OSDI test and a follow-up of non-invasive tests were performed on the patients in the sample to accept or discard the hypotheses raised. Results: Of the 394 patients visited on random days in the last weeks of March, 40 persons were studied. They were classified into three age ranges 65 years (37.50%). The sample had a higher percentage of women (77.50%). The percentage of women presenting severe or moderate dry eye symptomatology according to the OSDI test was higher than that of men and both the OSDI test and the non-invasive tests performed indicate an increase in prevalence with age. Conclusion: Age influences the presence of involvement and increases symptoms. Sex also influences the appearance of the syndrome, women are more prone to suffer from this multifactorial disease, which confirms the second working hypothesis. As for the physical, chemical and external factors, an influence of work activity and vitamin D deficiency can be detected, since in the tests carried out a slight peak of ocular dryness was observed in the 41 to 65 years age group, which is the group of the sample with the highest percentage of people who work and present a deficit of this vitamin

Autonomy, power dynamics and antibiotic use in primary healthcare: A qualitative study

Antibiotic resistance is a global health concern. Although numerous strategies have tried to reduce inadequate antibiotic prescribing, antibiotics are still prescribed in 60% of acute lower respiratory tract infections (ALRTIs) cases in Catalonia (Spain). This study aims to explore service users' experiences of ALRTIs, the quality and access to healthcare services, and health education. Selective purposive sampling was carried out, based on a prior definition of participant characteristics. These were sex, age, ethnicity, date of the last ALRTI, number of ALRTIs in the last year, and treatments received. Participants with a previous diagnosis of ALRTIs were recruited from three primary health care centres in Barcelona and one in Tarragona. Twenty-nine interviews were conducted between April and June 2019. A content thematic analysis was performed. Three themes were identified: 1) risk perceptions and help-seeking; 2) treatment preferences and antibiotic use; and 3) relationship dynamics and communication with healthcare professionals. Accounts of service users' sense of autonomy towards their health and power dynamics within the healthcare system were apparent. Supporting service users to become reliable, subjective and agentic experts of their health and bodies could help them to voice their healthcare agendas. Power structures embedded within healthcare, political and economic institutions should be challenged so that healthcare services can be co-developed (with service users) and based on service users' autonomy and horizontal relationships. Special consideration should be paid to the intersection of social vulnerabilities. A concordance approach to prescribing could be key to improve the responsible use of antibiotics and to contribute to the prevention of AMR in primary healthcare. The marketisation of health, and the increased demands of private healthcare in Spain due to the financial pressures on public healthcare as a consequence of the financial crisis of 2008 and the COVID-19 pandemic, are a risk for promoting adequate antibiotic prescribing and use. Trial registration The ISAAC-CAT study has been registered in the NCT registry, ID: NCT03931577

Estimación del coste hospitalario del cáncer colorrectal en Cataluña

Objetivo: Estimar el coste hospitalario del tratamiento del cáncer colorrectal (CCR) según estadio, tipo de coste y fase de evolución de la enfermedad en un hospital público. Métodos: Se realizó un estudio retrospectivo de costes de la atención hospitalaria del CCR de una cohorte de 699 pacientes con diagnóstico y tratamiento de CCR entre los a nos 2000 y 2006 en el Hospital del Mar, con seguimiento de hasta 5 a nos desde el diagnóstico de la enfermedad, a partir de bases de datos clínico-administrativas. Se analizó el coste medio por estadio, tipo de coste y fase de evolución de la enfermedad. Resultados: El coste medio por paciente en casos con diagnóstico in situ fue de 6573 D . Este coste aumentó en estadios más avanzados y llegó a los 36.894 D en el estadio III. Los principales componentes del coste fueron la cirugía-hospitalización (59,2%) y la quimioterapia (19,4%). En estadios más avanzados, el peso de la cirugía-hospitalización disminuyó, mientras que el de la quimioterapia aumentó. Conclusión: Este estudio proporciona el coste hospitalario del tratamiento del CCR calculado a partir de la práctica clínica habitual. La cirugía y el tratamiento quimioterápico son los principales componentes del coste. Los resultados obtenidos aportarán la información necesaria para los análisis de coste-efectividad de distintas iniciativas preventivas e innovaciones terapéuticas en nuestro entorno

Emergency hospital services utilization in Lleida (Spain): A cross-sectional study of immigrant and Spanish-born populations

<p>Abstract</p> <p>Background</p> <p>The use of emergency hospital services (EHS) has increased steadily in Spain in the last decade while the number of immigrants has increased dramatically. Studies show that immigrants use EHS differently than native-born individuals, and this work investigates demographics, diagnoses and utilization rates of EHS in Lleida (Spain).</p> <p>Methods</p> <p>Cross-sectional study of all the 96,916 EHS visits by patients 15 to 64 years old, attended during the years 2004 and 2005 in a public teaching hospital. Demographic data, diagnoses of the EHS visits, frequency of hospital admissions, mortality and diagnoses at hospital discharge were obtained. Utilization rates were estimated by group of origin. Poisson regression was used to estimate the rate ratios of being visited in the EHS with respect to the Spanish-born population.</p> <p>Results</p> <p>Immigrants from low-income countries use EHS services more than the Spanish-born population. Differences in utilization patterns are particularly marked for Maghrebi men and women and sub-Saharan women. Immigrant males are at lower risk of being admitted to the hospital, as compared with Spanish-born males. On the other hand, immigrant women are at higher risk of being admitted. After excluding the visits with gynecologic and obstetric diagnoses, women from sub-Saharan Africa and the Maghreb are still at a higher risk of being admitted than their Spanish-born counterparts.</p> <p>Conclusion</p> <p>In Lleida (Spain), immigrants use more EHS than the Spanish born population. Future research should indicate whether the same pattern is found in other areas of Spain and whether EHS use is attributable to health needs, barriers to access to the primary care services or similarities in the way immigrants access health care in their countries of origin.</p

Health Services Utilization, Work Absenteeism and Costs of Pandemic Influenza A (H1N1) 2009 in Spain: A Multicenter-Longitudinal Study

Background: The aim of this study was to estimate healthcare resource utilization, work absenteeism and cost per patient with pandemic influenza (H1N1)2009, from its beginning to March 2010, in Spain. We also estimated the economic impact on healthcare services. Methods and Findings: Longitudinal, descriptive,multicenter study of in- and outpatients with confirmed diagnosis of influenza A (H1N1) in Spain. Temporal distribution of cases was comparable to that in Spain. Information of healthcare and social resources used from one week before admission (inpatient) or index-medical visit (outpatient) until recovery was gathered. Unit cost was imputed to utilization frequency for the monetary valuation of use. Mean cost per patient was calculated. A sensitivity analysis was conducted, and variables correlated with cost per patient were identified. Economic impact on the healthcare system was estimated using healthcare costs per patient and both, the reported number of confirmed and clinical cases in Spain. 172 inpatients and 224 outpatients were included. Less than 10% were over 65 years old and more than 50% had previous comorbidities. 12.8% of inpatients were admitted to the Intensive Care Unit. Mean length of hospital stay of patients not requiring critical care was 5 days (SD =4.4). All working-inpatients and 91.7% working-outpatients went on sick leave. On average, work absenteeism was 30.5 days (SD=20.7) for the first ones and 9 days (SD= 6.3) for the latest. Caregivers of 21.7% of inpatients and 8.5% of outpatients also had work absenteeism during 10.7 and 4.1 days on average respectively. Mean cost was J6,236/inpatient (CI95%=1,384-14,623) and J940/outpatient (CI95% =66-3,064). The healthcare economic burden of patients with confirmed influenza was J144,773,577 (IC95% 13,753,043-383,467,535). More than 86% of expenditures were a result of outpatients" utilization. Conclusion: Cost per H1N1-patient did not defer much from seasonal influenza estimates. Hospitalizations and work absenteeism represented the highest cost per patient

Differences in pharmaceutical consumption and expenses between immigrant and Spanish-born populations in Lleida, (Spain): A 6-months prospective observational study

<p>Abstract</p> <p>Background</p> <p>There are few studies comparing pharmaceutical costs and the use of medications between immigrants and the autochthonous population in Spain. The objective of this study is to evaluate whether there are differences in pharmaceutical consumption and expenses between immigrant and Spanish-born populations.</p> <p>Methods</p> <p>Prospective observational study in 1,630 immigrants and 4,154 Spanish-born individuals visited by fifteen primary care physicians at five public Primary Care Clinics (PCC) during 2005 in the city of Lleida, Catalonia (Spain). Data on pharmaceutical consumption and expenses was obtained from a comprehensive computerized data-collection system. Multinomial regression models were used to estimate relative risks and confidence intervals of pharmaceutical expenditure, adjusting for age and sex.</p> <p>Results</p> <p>The percentage of individuals that purchased medications during a six-month period was 53.7% in the immigrant group and 79.2% in the autochthonous group. Pharmaceutical expenses and consumption were lower in immigrants than in autochthonous patients in all age groups and both genders. The relative risks of being in the highest quartile of expenditure, for Spanish-born versus immigrants, were 6.9, 95% CI = (4.2, 11.5) in men and 5.3, 95% CI = (3.5, 8.0) in women, with the reference category being not having any pharmaceutical expenditure.</p> <p>Conclusion</p> <p>Pharmaceutical expenses are much lower for immigrants with respect to autochthonous patients, both in the percentage of prescriptions filled at pharmacies and the number of containers of medication obtained, as well as the prices of the medications used. Future studies should explore which factors explain the observed differences in pharmaceutical expenses and if these disparities produce health inequalities.</p

In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study

Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson’s disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r =0.37, p <0.001), and this association remained significant after controlling for several potential confounding variables (p =0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p =0.02). Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition- relevant changes in non-demented PD

Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease

Altres ajuts: acord transformatiu CRUE-CSICBackground and purpose: Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood. Methods: The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used. Results: After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (β = 0.595; p < 0.0001). At the level of neural correlates, hypomimia was related to motor regions brodmann area 8 (BA 8) and to multiple fronto-temporo-parietal regions involved in the decoding, recognition and production of facial expression of emotions. Conclusion: Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge